The role of epithelial primary cilium in the development of hydrocephalus
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A finite elements study on the role of primary cilia in sensing mechanical stimuli to cells by calculating their response to the fluid flow
The primary cilium which is an organelle in nearly every cell in the vertebrate body extends out of the cell surface like an antenna and is known as cell sensor of mechanical and chemical stimuli. In previous numerical simulations, researchers modeled this organelle as a cantilevered beam attached to the cell surface. In the present study, however, we present a novel model that accommodates for...
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Radial glial cells (RCGs) are self-renewing progenitor cells that give rise to neurons and glia during embryonic development. Throughout neurogenesis, these cells contact the cerebral ventricles and bear a primary cilium. Although the role of the primary cilium in embryonic patterning has been studied, its role in brain ventricular morphogenesis is poorly characterized. Using conditional mutant...
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Hydrocephalus is an abnormal increase in the volume of cerebrospinal fluid (CSF), and sometimes increased intracerebral pressure also leads to hydrocephalus. Endoscopic Third Ventriculostomy (ETV) treatment is a new method for hydrocephaly treatment. In this method, in addition to the fact that the patient does not need an implant, the risk of infection is low and in the long term the result is...
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Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding proteins involved in ciliogenesis or protein transport to the primary cilia lead to a wide variety of diseases commonly referred to as ciliopathies,which include primary ciliary ...
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Nearly all vertebrate cells have a single cilium protruding from their surface. This threadlike organelle, once considered vestigial, is now seen as a pivotal element for detection of extracellular signals that trigger crucial morphogenetic pathways. We recently proposed a role for Dido3, the main product of the death inducer-obliterator (dido) gene, in histone deacetylase 6 delivery to the pri...
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تاریخ انتشار 2010